What is required for a mutation to be inherited?

For a mutation to be inherited, it must occur in germline cells, which are the reproductive cells (sperm and eggs) that contribute genetic information to the next generation. This means that any mutations present in these cells can be passed on to offspring during reproduction. If a mutation occurs in somatic cells, which are non-reproductive cells that make up most of an individual's body, it will not be passed on to the next generation, as these mutations do not affect the genetic material transmitted through gametes.

Additionally, mutations do not need to be advantageous in order to be inherited; they can be neutral or even harmful while still being passed on if they occur in germline cells. Permanent changes to RNA do not directly pertain to inheritance, as RNA is typically not the genetic material that is carried to the next generation; instead, it is DNA that is inherited. Thus, the requirement for inheritance is the occurrence of mutations in germline cells.