What is required for the formation of a polypeptide chain?

The formation of a polypeptide chain primarily requires peptide bonds between amino acids. Peptide bonds are covalent bonds that link the carboxyl group of one amino acid to the amino group of another, resulting in a chain-like structure as more amino acids are joined together. This process is fundamental in building proteins, as proteins are made up of long chains of amino acids that fold into specific shapes, enabling them to perform various functions in biological systems.

While condensation reactions are involved in forming peptide bonds, the crucial aspect that defines the creation of a polypeptide chain is indeed the formation of these peptide bonds. In this context, a condensation reaction occurs as water is released during the bond formation. Therefore, focusing specifically on the formation of the polypeptide chain leads to the conclusion that peptide bonds are the essential requirement for this process.