What is the primary purpose of naked monoclonal antibodies?

Naked monoclonal antibodies are designed primarily for their ability to directly bind to specific antigens on the surface of cancer cells, thus mediating immune responses against these cells. When these antibodies attach to their target, they can trigger various immune mechanisms, including the recruitment of other immune cells to attack and destroy the cancer cells. This targeted approach helps enhance the body's natural defenses and provides a way to combat tumors more effectively.

While other options mention beneficial actions such as delivering toxic payloads, stimulating organs, or increasing regulatory checkpoints, they do not encapsulate the fundamental role of naked monoclonal antibodies in direct immune modulation. Therefore, the correct answer reflects their main function focused on engaging the immune system against cancer, making them an essential tool in cancer immunotherapy.