What is the primary role of mast cells when they detect an injury?

The primary role of mast cells when they detect an injury is to release histamine and other chemicals. Mast cells are a type of immune cell that are primarily found in tissues such as the skin, lungs, and digestive tract. When they encounter an injury or an allergen, they become activated and release histamine and other inflammatory mediators, such as cytokines and leukotrienes.

Histamine plays a crucial role in inflammation by causing blood vessels to dilate and become more permeable, allowing more immune cells and proteins to reach the site of injury or infection quickly. This response helps initiate the healing process and can lead to the typical signs of inflammation, such as redness, swelling, and warmth. The release of other chemicals further amplifies the immune response and attracts additional white blood cells to the site.

Through this action, mast cells serve as a vital component of the body's immediate response to injury, protecting against infection and facilitating tissue repair.