Which aspect highlights a downside regarding the use of GMOs in terms of agriculture cost?

The option referring to legal issues associated with seed purchases underscores a significant concern about the use of genetically modified organisms (GMOs) in agriculture. Many GMO seeds are patented by companies, which means that farmers are often required to enter into licensing agreements to use the seeds. This can lead to increased costs for farmers, as they might need to pay for the rights to use the seeds each planting season, and they cannot save seeds from their harvest to replant the following year without incurring additional expenses or facing legal repercussions.

These legal considerations can create economic burdens for farmers, specifically smaller-scale operations that may already be under financial strain. The complexities of navigating these legalities can deter some farmers from using GMOs, despite potential benefits, emphasizing the high price and corporate control over these agricultural innovations.

In contrast, the other options present more positive implications regarding GMOs. The reduction in dependency on chemical fertilizers and increased sustainability are typically seen as advantages, while lower overall crop yields is not generally a recognized benefit of GMOs, which are often engineered to enhance yields.